2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. (-)-Aspartic acid

(-)-Aspartic acid  (Synonyms: (R)-Aspartic acid; D-(-)-Aspartic acid)

Cat. No.: HY-42068 Purity: ≥98.0%
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(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system.

For research use only. We do not sell to patients.

(-)-Aspartic acid Chemical Structure

(-)-Aspartic acid Chemical Structure

CAS No. : 1783-96-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water USD 55 In-stock
Solid
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5 g USD 60 In-stock
25 g USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (-)-Aspartic acid:

(-)-Aspartic acid Related Antibodies

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Description

(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system[5].
Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
398 μM
Compound: D-asp
Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells
Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells
[PMID: 35677430]
In Vitro

(-)-Aspartic acid (1, 10, 30 mM) inhibits HGF cell pyroptosis through the TLRs-NLRP3-caspase 1-GSDMD pathway to prevent gingival fibroblast inflammation[1].
(-)-Aspartic acid (0.1, 1, 10 nM, 48 h) stimulates steroid production in mammalian Leydig cell lines by regulating LH receptor (LHR) exposure on the cell membrane[2].
(-)-Aspartic acid acts as a neuropeptide co transmitter by releasing glutamate or GABA as its main neurotransmitter pathway [5].
(-)-Aspartic acidactivates cAMP dependent gene transcription, inhibits CREB function, reduces BDNF expression, and induces excitotoxic neuronal death[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Aspartic acid Related Antibodies

Real Time qPCR[1].

Cell Line: Human gingival fibroblasts (HGFs)
Concentration: 1, 10, 30 mM
Incubation Time:
Result: Inhibited the expression of NLRP3, caspase-1, GSDMD, IL-1 β, and IL-18 genes

Western Blot Analysis[2].

Cell Line: MA-10 cell
Concentration: 0.1, 1, 10 nM
Incubation Time: 48 h
Result: Increased the expression level of steroidogenic acute regulatory (StAR) protein with hCG
In Vivo

(-)-Aspartic acid (0.5, 1, 2, 4 μmol/g; i.p.) participates in the synthesis of testosterone in rats[3].
(-)-Aspartic acid (2 μmol/g; i.p.) increases the secretion of gonadotropin-releasing hormone (GnRH), prolactin (PRL), luteinizing hormone (LH), and growth hormone (GH) in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male rats[3].
Dosage: 0.5, 1, 2, 4 μmol/g
Administration: Intraperitoneal injection (i.p.)
Result: Increased production of LH, testosterone, and progesterone in the blood.
Animal Model: 85-day-old male rats[4].
Dosage: 2.0 μmol/g
Administration: Intraperitoneal injection (i.p.)
Result: Increased levels of gonadotropin-releasing hormone (GnRH), prolactin (PRL), luteinizing hormone (LH), and growth hormone (GH) in rats.
Molecular Weight

133.10

Formula

C4H7NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C(O)=O)CC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 7.69 mg/mL (57.78 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5131 mL 37.5657 mL 75.1315 mL
5 mM 1.5026 mL 7.5131 mL 15.0263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (15.03 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.5131 mL 37.5657 mL 75.1315 mL 187.8287 mL
5 mM 1.5026 mL 7.5131 mL 15.0263 mL 37.5657 mL
10 mM 0.7513 mL 3.7566 mL 7.5131 mL 18.7829 mL
15 mM 0.5009 mL 2.5044 mL 5.0088 mL 12.5219 mL
20 mM 0.3757 mL 1.8783 mL 3.7566 mL 9.3914 mL
25 mM 0.3005 mL 1.5026 mL 3.0053 mL 7.5131 mL
30 mM 0.2504 mL 1.2522 mL 2.5044 mL 6.2610 mL
40 mM 0.1878 mL 0.9391 mL 1.8783 mL 4.6957 mL
50 mM 0.1503 mL 0.7513 mL 1.5026 mL 3.7566 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(-)-Aspartic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Aspartic acid1783-96-6(R)-Aspartic acid D-(-)-Aspartic acidPyroptosisendogenous amino acidsneurological developmentendocrine systemInhibitorinhibitorinhibit

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