2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. (±)-1,2-Propanediol

(±)-1,2-Propanediol  (Synonyms: 1,2-(RS)-Propanediol; 1,2-Propylene glycol; Propylene glycol)

Cat. No.: HY-Y0921 Purity: 99.98%
COA Handling Instructions

Molarity Calculator

(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.

For research use only. We do not sell to patients.

(±)-1,2-Propanediol Chemical Structure

(±)-1,2-Propanediol Chemical Structure

CAS No. : 57-55-6

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Based on 1 publication(s) in Google Scholar

Other Forms of (±)-1,2-Propanediol:

(±)-1,2-Propanediol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (±)-1,2-Propanediol

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

76.09

Formula

C3H8O2
CAS No.
Appearance

Liquid (Density: 1.036 g/cm3)

Color

Colorless to light yellow

SMILES

CC(O)CO
Initial Source

Clostridium strain AK1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1314.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (1314.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.1423 mL 65.7117 mL 131.4233 mL
5 mM 2.6285 mL 13.1423 mL 26.2847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

COA (246 KB) HNMR (115 KB) GC (192 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 13.1423 mL 65.7117 mL 131.4233 mL 328.5583 mL
5 mM 2.6285 mL 13.1423 mL 26.2847 mL 65.7117 mL
10 mM 1.3142 mL 6.5712 mL 13.1423 mL 32.8558 mL
15 mM 0.8762 mL 4.3808 mL 8.7616 mL 21.9039 mL
20 mM 0.6571 mL 3.2856 mL 6.5712 mL 16.4279 mL
25 mM 0.5257 mL 2.6285 mL 5.2569 mL 13.1423 mL
30 mM 0.4381 mL 2.1904 mL 4.3808 mL 10.9519 mL
40 mM 0.3286 mL 1.6428 mL 3.2856 mL 8.2140 mL
50 mM 0.2628 mL 1.3142 mL 2.6285 mL 6.5712 mL
60 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4760 mL
80 mM 0.1643 mL 0.8214 mL 1.6428 mL 4.1070 mL
100 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2856 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(±)-1,2-Propanediol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-1,2-Propanediol57-55-61,2-(RS)-Propanediol 1,2-Propylene glycol Propylene glycolEndogenous Metabolite1,2-Propanediol (propylene glycol)ZebrafishBehaviorNeural and vascular developmentInhibitorinhibitorinhibit

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