β-Glycerophosphate disodium salt pentahydrate

Name: β-Glycerophosphate disodium salt pentahydrate
Brand: MedChemExpress
SKU: HY-D0886
Rating: 5.0 (7 reviews)

Cat. No.: HY-D0886 Purity: 99.81%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.

For research use only. We do not sell to patients.

β-Glycerophosphate disodium salt pentahydrate Chemical Structure

CAS No. : 13408-09-8

Size	Price	Stock	Quantity
5 g	USD 25	In-stock	Estimated Time of Arrival: December 31
10 g	USD 33	In-stock	Estimated Time of Arrival: December 31
25 g	USD 50	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Based on 7 publication(s) in Google Scholar

Other Forms of β-Glycerophosphate disodium salt pentahydrate:

β-Glycerophosphate disodium salt hydrate Get quote
Glycerophosphoric acid disodium salt hydrate (α and β mixture) Get quote

7 Publications Citing Use of MCE β-Glycerophosphate disodium salt pentahydrate

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

ERK1

ERK2

In Vitro

β-Glycerophosphate disodium salt pentahydrate, as a phosphate source of the bone mineral hydroxyapatite, can promote osteogenic differentiation and further induce osteogenic gene expression through phosphorylation of the cytokinase-associated kinase ERK1/2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

306.11

Formula

C₃H₁₇Na₂O₁₁P

CAS No.

13408-09-8

Appearance

Solid

Color

White to yellow

SMILES

OCC(OP(O[Na])(O[Na])=O)CO.[5H2O]

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 83.33 mg/mL (272.22 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2668 mL	16.3340 mL	32.6680 mL
5 mM	0.6534 mL	3.2668 mL	6.5336 mL
10 mM	0.3267 mL	1.6334 mL	3.2668 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (326.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (253 KB) HNMR (246 KB) RP-HPLC (230 KB)

Handling Instructions (2659 KB)

References

[1]. Belfield A, et al. Inhibition of the nucleotidase effect of alkaline phosphatase by beta-glycerophosphate. Nature. 1968 Jul 6;219(5149):73-5. [Content Brief]

[2]. Langenbach F, et al. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013;4(5):117.

[3]. Chung CH, et al. Mechanism of action of beta-glycerophosphate on bone cell mineralization. Calcif Tissue Int. 1992;51(4):305-311. [Content Brief]

[4]. Li C, et al. Efficacy, pharmacokinetics, and biodistribution of thermosensitive chitosan/β-glycerophosphate hydrogel loaded with docetaxel. AAPS PharmSciTech. 2014 Apr;15(2):417-24.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.2668 mL	16.3340 mL	32.6680 mL	81.6700 mL
	5 mM	0.6534 mL	3.2668 mL	6.5336 mL	16.3340 mL
	10 mM	0.3267 mL	1.6334 mL	3.2668 mL	8.1670 mL
	15 mM	0.2178 mL	1.0889 mL	2.1779 mL	5.4447 mL
	20 mM	0.1633 mL	0.8167 mL	1.6334 mL	4.0835 mL
	25 mM	0.1307 mL	0.6534 mL	1.3067 mL	3.2668 mL
	30 mM	0.1089 mL	0.5445 mL	1.0889 mL	2.7223 mL
	40 mM	0.0817 mL	0.4083 mL	0.8167 mL	2.0417 mL
	50 mM	0.0653 mL	0.3267 mL	0.6534 mL	1.6334 mL
	60 mM	0.0544 mL	0.2722 mL	0.5445 mL	1.3612 mL
	80 mM	0.0408 mL	0.2042 mL	0.4083 mL	1.0209 mL
	100 mM	0.0327 mL	0.1633 mL	0.3267 mL	0.8167 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.