2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. β-Melanocyte Stimulating Hormone (MSH), human

β-Melanocyte Stimulating Hormone (MSH), human  (Synonyms: Beta-MSH (1-22) (human))

Cat. No.: HY-P1504 Purity: 98.91%
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β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.

For research use only. We do not sell to patients.

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β-Melanocyte Stimulating Hormone (MSH), human Chemical Structure

β-Melanocyte Stimulating Hormone (MSH), human Chemical Structure

CAS No. : 17908-57-5

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1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 910 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of β-Melanocyte Stimulating Hormone (MSH), human:

β-Melanocyte Stimulating Hormone (MSH), human Related Antibodies

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Description

β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist[1].

IC50 & Target

MC4R

 

In Vitro

β-Melanocyte Stimulating Hormone (MSH), human (β-MSH) has high affinity at both human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=5.0±0.4 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Melanocyte Stimulating Hormone (MSH), human Related Antibodies
Molecular Weight

2660.92

Formula

C118H174N34O35S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp
Sequence Shortening

AEKKDEGPYRMEHFRWGSPPKD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (37.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3758 mL 1.8790 mL 3.7581 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3758 mL 1.8790 mL 3.7581 mL 9.3952 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL 1.8790 mL
10 mM 0.0376 mL 0.1879 mL 0.3758 mL 0.9395 mL
15 mM 0.0251 mL 0.1253 mL 0.2505 mL 0.6263 mL
20 mM 0.0188 mL 0.0940 mL 0.1879 mL 0.4698 mL
25 mM 0.0150 mL 0.0752 mL 0.1503 mL 0.3758 mL
30 mM 0.0125 mL 0.0626 mL 0.1253 mL 0.3132 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Melanocyte Stimulating Hormone (MSH), human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Melanocyte Stimulating Hormone (MSH), human17908-57-5Beta-MSH (1-22) (human)Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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