2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite CaSR
  4. γ-L-Glutamyl-L-alanine

γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function.

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γ-L-Glutamyl-L-alanine Chemical Structure

γ-L-Glutamyl-L-alanine Chemical Structure

CAS No. : 5875-41-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

γ-L-Glutamyl-L-alanine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE γ-L-Glutamyl-L-alanine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

γ-L-Glutamyl-L-alanine (γ-Glu-Ala) shows the potency for Ca2+i mobilization in CaR (calcium-sensing receptor)-expressing HEK-293 cells, with an EC50 of 4.8 µM[3].
γ-L-Glutamyl-L-alanine shows the potency for Ca2+i mobilization in human parathyroid cells with an EC50 of 13.9 µM[3].
γ-L-Glutamyl-L-alanine (20 μM) suppress PTH secretion from normal human parathyroid cells[3].
γ-L-Glutamyl-L-alanine is a substrate for glutaminase B[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-L-Glutamyl-L-alanine Related Antibodies
Molecular Weight

218.21

Formula

C8H14N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CCC(N[C@@H](C)C(O)=O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (229.14 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5827 mL 22.9137 mL 45.8274 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (458.27 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5827 mL 22.9137 mL 45.8274 mL 114.5685 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL 22.9137 mL
10 mM 0.4583 mL 2.2914 mL 4.5827 mL 11.4569 mL
15 mM 0.3055 mL 1.5276 mL 3.0552 mL 7.6379 mL
20 mM 0.2291 mL 1.1457 mL 2.2914 mL 5.7284 mL
25 mM 0.1833 mL 0.9165 mL 1.8331 mL 4.5827 mL
30 mM 0.1528 mL 0.7638 mL 1.5276 mL 3.8190 mL
40 mM 0.1146 mL 0.5728 mL 1.1457 mL 2.8642 mL
50 mM 0.0917 mL 0.4583 mL 0.9165 mL 2.2914 mL
60 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9095 mL
80 mM 0.0573 mL 0.2864 mL 0.5728 mL 1.4321 mL
100 mM 0.0458 mL 0.2291 mL 0.4583 mL 1.1457 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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γ-L-Glutamyl-L-alanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-L-Glutamyl-L-alanine5875-41-2Endogenous MetaboliteCaSRCalcium-sensing receptorPTHCa2+parathyroid cellHEK293Inhibitorinhibitorinhibit

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