A 410099.1, amine-Boc hydrochloride

Cat. No.: HY-136269 Purity: 95.03%: FAQs
Data Sheet SDS COA Handling Instructions

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A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5).

For research use only. We do not sell to patients.

A 410099.1, amine-Boc hydrochloride Chemical Structure

CAS No. : 2374122-37-7

Size	Price	Stock	Quantity
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 295	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 440	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of A 410099.1, amine-Boc hydrochloride:

A 410099.1, amine-Boc Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5)^[1].

IC₅₀ & Target

cIAP1

Molecular Weight

620.22

Formula

C₃₂H₅₀ClN₅O₅

CAS No.

2374122-37-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C[C@H]1N)[C@@H](C1)C(N[C@H]2C3=CC=CC=C3CCC2)=O)[C@H](C4CCCCC4)NC([C@H](C)N(C)C(OC(C)(C)C)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (161.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6123 mL	8.0617 mL	16.1233 mL
5 mM	0.3225 mL	1.6123 mL	3.2247 mL
10 mM	0.1612 mL	0.8062 mL	1.6123 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.03%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (255 KB) HNMR (230 KB) RP-HPLC (225 KB) MS (181 KB)

Handling Instructions (2659 KB)

References

[1]. Christopher P Tinworth, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol.2019 Mar 15;14(3):342-347 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6123 mL	8.0617 mL	16.1233 mL	40.3083 mL
	5 mM	0.3225 mL	1.6123 mL	3.2247 mL	8.0617 mL
	10 mM	0.1612 mL	0.8062 mL	1.6123 mL	4.0308 mL
	15 mM	0.1075 mL	0.5374 mL	1.0749 mL	2.6872 mL
	20 mM	0.0806 mL	0.4031 mL	0.8062 mL	2.0154 mL
	25 mM	0.0645 mL	0.3225 mL	0.6449 mL	1.6123 mL
	30 mM	0.0537 mL	0.2687 mL	0.5374 mL	1.3436 mL
	40 mM	0.0403 mL	0.2015 mL	0.4031 mL	1.0077 mL
	50 mM	0.0322 mL	0.1612 mL	0.3225 mL	0.8062 mL
	60 mM	0.0269 mL	0.1344 mL	0.2687 mL	0.6718 mL
	80 mM	0.0202 mL	0.1008 mL	0.2015 mL	0.5039 mL
	100 mM	0.0161 mL	0.0806 mL	0.1612 mL	0.4031 mL