2. Metabolic Enzyme/Protease
  3. Renin
  4. A-74273

A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.

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A-74273 Chemical Structure

A-74273 Chemical Structure

CAS No. : 130316-95-9

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Description

A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension[1][2].

Molecular Weight

787.08

Formula

C44H74N4O8
CAS No.
SMILES

CCCC[C@H](O[C@H](C(N1CCC(OCOC)CC1)=O)CC2=CC=CC=C2)C(NC(C(O)C[C@H](C(NCCCN3CCOCC3)=O)C(C)C)CC4CCCCC4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A-74273 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-74273130316-95-9A74273A 74273Reninpeptiderenincompetitive inhibitorvascular tensionhigh blood pressureInhibitorinhibitorinhibit

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