2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. A1899

A1899 is a potent and highly selective blocker of the K2P channel TASK-1. A1899 has IC50 values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an IKur blocker that can be used for the research of cardiovascular diseases.

For research use only. We do not sell to patients.

A1899 Chemical Structure

A1899 Chemical Structure

CAS No. : 498577-46-1

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Based on 1 publication(s) in Google Scholar

A1899 Related Antibodies

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Description

A1899 is a potent and highly selective blocker of the K2P channel TASK-1. A1899 has IC50 values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an IKur blocker that can be used for the research of cardiovascular diseases[1][2].

IC50 & Target

TASK-1

0.035 μM (IC50)

TASK-3

0.318 pg/mL (IC50)

TASK-2

12 μM (IC50)

TASK-4

8.1 μM (IC50)

TREK-1

23.8 μM (pIC50)

TREK-2

8.4 μM (IC50)

TRAAK

>20 μM (IC50)

THIK-1

2.2 μM (IC50)

TRESK

0.9 μM (IC50)

Kv1.1

2.7 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.007 μM
Compound: 1; A1899
Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
Inhibition of human TASK1 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
[PMID: 31260312]
CHO IC50
0.07 μM
Compound: 1; A1899
Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
Inhibition of human TASK3 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
[PMID: 31260312]
CHO IC50
12 μM
Compound: 1; A1899
Inhibition of human TASK2 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
Inhibition of human TASK2 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
[PMID: 31260312]
CHO IC50
7 nM
Compound: 1, A-1899
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay
Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay
[PMID: 25017033]
CHO IC50
8.1 μM
Compound: 1; A1899
Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay
[PMID: 31260312]
Molecular Weight

500.54

Formula

C30H26F2N2O3
CAS No.
SMILES

O=C(C1=CC=CC=C1C2=CC=CC=C2CNC(CC3=CC=C(OC)C=C3)=O)NCC4=CC=C(F)C=C4F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A1899 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A1899498577-46-1S20951A 1899A-1899S 20951S-20951Potassium ChannelKcsATASK-1 channels blockeroocytesCHO cellscardiovascular diseasesIKur blockerInhibitorinhibitorinhibit

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