2. Neuronal Signaling
  3. Sigma Receptor
  4. AB21 oxalate

AB21 oxalate is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity.

For research use only. We do not sell to patients.

AB21 oxalate Chemical Structure

AB21 oxalate Chemical Structure

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AB21 oxalate Related Antibodies

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Description

AB21 oxalate is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity[1].

In Vitro

AB21 oxalate shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB21 oxalate Related Antibodies
In Vivo

AB21 oxalate (20 mg/kg, s.c., administered 30 min before the injection of Capsaicin (HY-10448)) reverses mechanical allodyniain in Capsaicin (HY-B0448)-induced pain model, and exhibits higher potency than BD1063 dhydrochloride (HY-18101A)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

438.52

Formula

C25H30N2O5
SMILES

OC(C(O)=O)=O.O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB21 oxalate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB21AB 21AB-21Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivityInhibitorinhibitorinhibit

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AB21 oxalate
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HY-149854A
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