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  3. AB21 hydrochloride

AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity.

For research use only. We do not sell to patients.

AB21 hydrochloride Chemical Structure

AB21 hydrochloride Chemical Structure

CAS No. : 3026677-24-4

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Description

AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity[1].

In Vitro

AB21 hydrochloride shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AB21 hydrochloride (20 mg/kg, s.c., administered 30 min before the injection of Capsaicin (HY-10448)) reverses mechanical allodyniain in Capsaicin (HY-B0448)-induced pain model, and exhibits higher potency than BD1063 dhydrochloride (HY-18101A)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Capsaicin-induced mechanical hypersensitivity model in mice[1].
Dosage: 20 mg/kg
Administration: Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin.
Result: Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).
Molecular Weight

384.94

Formula

C23H29ClN2O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (21.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5978 mL 12.9890 mL 25.9781 mL
5 mM 0.5196 mL 2.5978 mL 5.1956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5978 mL 12.9890 mL 25.9781 mL 64.9452 mL
5 mM 0.5196 mL 2.5978 mL 5.1956 mL 12.9890 mL
10 mM 0.2598 mL 1.2989 mL 2.5978 mL 6.4945 mL
15 mM 0.1732 mL 0.8659 mL 1.7319 mL 4.3297 mL
20 mM 0.1299 mL 0.6495 mL 1.2989 mL 3.2473 mL
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AB21 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AB21 hydrochloride
Cat. No.:
HY-149854B
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