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  4. AB25583

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research.

For research use only. We do not sell to patients.

AB25583 Chemical Structure

AB25583 Chemical Structure

CAS No. : 2565637-94-5

Size Price Stock Quantity
5 mg USD 390 In-stock
10 mg USD 580 In-stock
25 mg USD 1080 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AB25583 is a Polθ helicase (Polθ-hel) small molecule inhibitor, with an IC50 value of 6 nM. AB25583 selectively kills BRCA1/2 deficient cells and works in synergy with Olaparib (HY-10162) in cancer cells carrying pathogenic BRCA1/2 mutations. AB25583 can be used for tumor research[1].
Molecular Weight

452.91

Formula

C22H17ClN4O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2079 mL 11.0397 mL 22.0794 mL
5 mM 0.4416 mL 2.2079 mL 4.4159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2079 mL 11.0397 mL 22.0794 mL 55.1986 mL
5 mM 0.4416 mL 2.2079 mL 4.4159 mL 11.0397 mL
10 mM 0.2208 mL 1.1040 mL 2.2079 mL 5.5199 mL
15 mM 0.1472 mL 0.7360 mL 1.4720 mL 3.6799 mL
20 mM 0.1104 mL 0.5520 mL 1.1040 mL 2.7599 mL
25 mM 0.0883 mL 0.4416 mL 0.8832 mL 2.2079 mL
30 mM 0.0736 mL 0.3680 mL 0.7360 mL 1.8400 mL
40 mM 0.0552 mL 0.2760 mL 0.5520 mL 1.3800 mL
50 mM 0.0442 mL 0.2208 mL 0.4416 mL 1.1040 mL
60 mM 0.0368 mL 0.1840 mL 0.3680 mL 0.9200 mL
80 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6900 mL
100 mM 0.0221 mL 0.1104 mL 0.2208 mL 0.5520 mL
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AB25583 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB255832565637-94-5AB 25583AB-25583OthersPolθ-helBRCA1/2tumorInhibitorinhibitorinhibit

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