2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Abelacimab

Abelacimab  (Synonyms: MAA868)

Cat. No.: HY-P99415 Purity: 98.63%
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Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies.

For research use only. We do not sell to patients.

CAS No. : 2098724-83-3

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Abelacimab Related Antibodies

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Description

Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies[1][2].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
In Vitro

Abelacimab (MAA868) (0.0001-1 μM) prolongs the clotting time and reduces the amount of thrombin in human plasma in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abelacimab Related Antibodies
In Vivo

Abelacimab (MAA868) (s.c., 3-30 mg/kg, on day 1, 85, 114) shows strong and sustained anticoagulant effects in crab-eating monkeys, significantly prolongs aPTT and has a good safety profile, with no significant toxic findings or signs of bleeding observed[1].
Abelacimab (MAA868) (i.v., 0.6 mg/kg) exhibits good anticoagulant activity to prevent carotid artery occlusion in iron chloride induced thrombosis FXI-/- C57BL/6 mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Abelacimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized Human Factor XI Protein (His Tag) can bind Abelacimab. The EC50 for this effect is 1.40 ng/mL.
Purity & Documentation

Purity: 98.63%

SDS (251 KB)

COA (231 KB) SDS-PAGE (95 KB) SEC-HPLC (93 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Abelacimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abelacimab2098724-83-3MAA868MAA 868MAA-868Factor XaFxaFXIFXIIathrombinthromboembolicmonoclonal antibodyIgG1Inhibitorinhibitorinhibit

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