2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. Ac-FEID-CMK TFA

Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-FEID-CMK TFA Chemical Structure

Ac-FEID-CMK TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 200 In-stock
5 mg USD 440 In-stock
10 mg USD 700 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway[1].

Molecular Weight

711.08

Formula

C29H38ClF3N4O11
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (35.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4063 mL 7.0316 mL 14.0631 mL
5 mM 0.2813 mL 1.4063 mL 2.8126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4063 mL 7.0316 mL 14.0631 mL 35.1578 mL
5 mM 0.2813 mL 1.4063 mL 2.8126 mL 7.0316 mL
10 mM 0.1406 mL 0.7032 mL 1.4063 mL 3.5158 mL
15 mM 0.0938 mL 0.4688 mL 0.9375 mL 2.3439 mL
20 mM 0.0703 mL 0.3516 mL 0.7032 mL 1.7579 mL
25 mM 0.0563 mL 0.2813 mL 0.5625 mL 1.4063 mL
30 mM 0.0469 mL 0.2344 mL 0.4688 mL 1.1719 mL
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Ac-FEID-CMK TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-FEID-CMKPyroptosisInflammatoryZF4 cellscaspy2pyroptosisAKIacute kidney injuryseptic shockInhibitorinhibitorinhibit

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