2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Acasunlimab

Acasunlimab  (Synonyms: GEN1046)

Cat. No.: HY-P99419 Purity: 99.90%
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Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer.

For research use only. We do not sell to patients.

CAS No. : 2253937-12-9

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1 mg USD 750 In-stock
5 mg USD 1950 In-stock
10 mg USD 3120 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer[1][2].

Isotype

Ig(G1-kappa_G1-lambda2)
Species

Humanized
In Vitro

Acasunlimab (GEN1046; 0.001-1 μM; 0-525 min) promotes interactions between dendritic cells and T cells and enhances T-cell activation[1].
Acasunlimab (0.001-1 μM; 48 h; PD-L1+ Tumor Cells) induces dose-dependent, conditional T-cell proliferation and cytokine production and enhances antigen-specific T-cell–mediated cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acasunlimab Related Antibodies
In Vivo

Acasunlimab (GEN1046; 5 mg/kg; twice weekly for three cycles) has antitumor activity and inhibits tumor growth in double knock-in (dKI) transgenic C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Double knock-in (dKI) transgenic C57BL/6 mice[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; twice weekly for three cycles
Result: Had antitumor activity in double knock-in (dKI) transgenic C57BL/6 mice.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Acasunlimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Ig(G1-kappa_G1-lambda2)
Purity & Documentation
References
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Acasunlimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acasunlimab2253937-12-9GEN1046GEN 1046GEN-1046PD-1/PD-L1PD-1/Programmed death-ligand 1T-cellNK-cellPD-1/PD-L1 inhibitory axiscancerdendritic cellsInhibitorinhibitorinhibit

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