Acemetacin-¹³C₆  (Synonyms: TVX 1322-¹³C₆)

Acemetacin-¹³C₆ (TVX 1322-¹³C₆) is ¹³C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

417.75

C₁₅¹³C₆H₁₄ClNO₆

53164-05-9

O=C(OCC(O)=O)CC1=C(C)N(C([13C]2=[13C][13C]=[13C](Cl)[13C]=[13C]2)=O)C3=C1C=C(OC)C=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Tavares IA, et al. Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage. J Gastroenterol Hepatol. 1998 Nov;13(S3):S190-S192.  [Content Brief]