2. Metabolic Enzyme/Protease Anti-infection
  3. Acetyl-CoA Carboxylase Bacterial
  4. Acetyl-CoA Carboxylase-IN-1

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity.

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Acetyl-CoA Carboxylase-IN-1 Chemical Structure

Acetyl-CoA Carboxylase-IN-1 Chemical Structure

CAS No. : 179343-23-8

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Based on 1 publication(s) in Google Scholar

Acetyl-CoA Carboxylase-IN-1 Related Antibodies

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  • Purity & Documentation

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Description

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].

In Vitro

Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; E. coli) has antibacterial activity with MIC values of >25, 3.13, 25, 0.39, 1.56, 0.1 μM for WT, WT+ PMBN, ΔacrAB, ΔacrAB+PMBN, ΔtolC, and ΔtolC+ PMBN, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetyl-CoA Carboxylase-IN-1 Related Antibodies
Molecular Weight

395.05

Formula

C13H9Br2N5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=C(C2=CC3=CN=C(N=C3N=C2N)N)C(Br)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (84.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5313 mL 12.6566 mL 25.3133 mL
5 mM 0.5063 mL 2.5313 mL 5.0627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5313 mL 12.6566 mL 25.3133 mL 63.2831 mL
5 mM 0.5063 mL 2.5313 mL 5.0627 mL 12.6566 mL
10 mM 0.2531 mL 1.2657 mL 2.5313 mL 6.3283 mL
15 mM 0.1688 mL 0.8438 mL 1.6876 mL 4.2189 mL
20 mM 0.1266 mL 0.6328 mL 1.2657 mL 3.1642 mL
25 mM 0.1013 mL 0.5063 mL 1.0125 mL 2.5313 mL
30 mM 0.0844 mL 0.4219 mL 0.8438 mL 2.1094 mL
40 mM 0.0633 mL 0.3164 mL 0.6328 mL 1.5821 mL
50 mM 0.0506 mL 0.2531 mL 0.5063 mL 1.2657 mL
60 mM 0.0422 mL 0.2109 mL 0.4219 mL 1.0547 mL
80 mM 0.0316 mL 0.1582 mL 0.3164 mL 0.7910 mL
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Acetyl-CoA Carboxylase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetyl-CoA Carboxylase-IN-1179343-23-8Acetyl-CoA CarboxylaseBacterialACC, Acetyl Coenzyme A CarboxylaseantibacterialMICE. coliInhibitorinhibitorinhibit

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