2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. nAChR Calcium Channel Endogenous Metabolite
  4. Acetylcholine-d4 chloride

Acetylcholine-d4 chloride  (Synonyms: ACh-d4 (chloride))

Cat. No.: HY-B0282S Purity: 99.07%
COA Handling Instructions

Molarity Calculator

Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

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Acetylcholine-d<sub>4</sub> chloride Chemical Structure

Acetylcholine-d4 chloride Chemical Structure

CAS No. : 344298-94-8

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5 mg USD 240 In-stock
10 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Acetylcholine-d4 chloride:

Acetylcholine-d4 chloride Related Antibodies

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Description

Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetylcholine-d4 chloride Related Antibodies
Molecular Weight

185.69

Formula

C7H12D4ClNO2
CAS No.
Unlabeled CAS

60-31-1
Appearance

Solid

Color

White to off-white

SMILES

CC(OC([2H])([2H])C([2H])([2H])[N+](C)(C)C)=O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (538.53 mM; Need ultrasonic)

DMSO : 50 mg/mL (269.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (269.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3853 mL 26.9266 mL 53.8532 mL
5 mM 1.0771 mL 5.3853 mL 10.7706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.07%

COA (251 KB) HNMR (145 KB) RP-HPLC (81 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO / H2O 1 mM 5.3853 mL 26.9266 mL 53.8532 mL 134.6330 mL
5 mM 1.0771 mL 5.3853 mL 10.7706 mL 26.9266 mL
10 mM 0.5385 mL 2.6927 mL 5.3853 mL 13.4633 mL
15 mM 0.3590 mL 1.7951 mL 3.5902 mL 8.9755 mL
20 mM 0.2693 mL 1.3463 mL 2.6927 mL 6.7316 mL
25 mM 0.2154 mL 1.0771 mL 2.1541 mL 5.3853 mL
30 mM 0.1795 mL 0.8976 mL 1.7951 mL 4.4878 mL
40 mM 0.1346 mL 0.6732 mL 1.3463 mL 3.3658 mL
50 mM 0.1077 mL 0.5385 mL 1.0771 mL 2.6927 mL
60 mM 0.0898 mL 0.4488 mL 0.8976 mL 2.2439 mL
80 mM 0.0673 mL 0.3366 mL 0.6732 mL 1.6829 mL
100 mM 0.0539 mL 0.2693 mL 0.5385 mL 1.3463 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acetylcholine-d4 chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetylcholine-d4344298-94-8ACh-d4nAChRCalcium ChannelEndogenous MetaboliteNicotinic acetylcholine receptorsCa2+ channelsCa channelsInhibitorinhibitorinhibit

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