Acetylcholine-d₄ chloride (Synonyms: ACh-d₄ (chloride))

Name: Acetylcholine-d 4 chloride
Brand: MedChemExpress
SKU: HY-B0282S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0282S Purity: 99.07%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Acetylcholine-d₄ (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

For research use only. We do not sell to patients.

Acetylcholine-d<sub>4</sub> chloride Chemical Structure

Acetylcholine-d₄ chloride Chemical Structure

CAS No. : 344298-94-8

Size	Price	Stock	Quantity
1 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acetylcholine-d₄ chloride:

Acetylcholine chloride In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

View All Isoforms

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

185.69

Formula

C₇H₁₂D₄ClNO₂

CAS No.

344298-94-8

Unlabeled CAS

60-31-1

Appearance

Solid

Color

White to off-white

SMILES

CC(OC([2H])([2H])C([2H])([2H])[N+](C)(C)C)=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (538.53 mM; Need ultrasonic)

DMSO : 50 mg/mL (269.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3853 mL	26.9266 mL	53.8532 mL
5 mM	1.0771 mL	5.3853 mL	10.7706 mL
10 mM	0.5385 mL	2.6927 mL	5.3853 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.07%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB) HNMR (145 KB) RP-HPLC (81 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.

[3]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9. [Content Brief]

[4]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41. [Content Brief]

[5]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2. [Content Brief]

[6]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO / H₂O	1 mM	5.3853 mL	26.9266 mL	53.8532 mL	134.6330 mL
	5 mM	1.0771 mL	5.3853 mL	10.7706 mL	26.9266 mL
	10 mM	0.5385 mL	2.6927 mL	5.3853 mL	13.4633 mL
	15 mM	0.3590 mL	1.7951 mL	3.5902 mL	8.9755 mL
	20 mM	0.2693 mL	1.3463 mL	2.6927 mL	6.7316 mL
	25 mM	0.2154 mL	1.0771 mL	2.1541 mL	5.3853 mL
	30 mM	0.1795 mL	0.8976 mL	1.7951 mL	4.4878 mL
	40 mM	0.1346 mL	0.6732 mL	1.3463 mL	3.3658 mL
	50 mM	0.1077 mL	0.5385 mL	1.0771 mL	2.6927 mL
	60 mM	0.0898 mL	0.4488 mL	0.8976 mL	2.2439 mL
	80 mM	0.0673 mL	0.3366 mL	0.6732 mL	1.6829 mL
	100 mM	0.0539 mL	0.2693 mL	0.5385 mL	1.3463 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Acetylcholine-d₄ chloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetylcholine-d₄344298-94-8ACh-d₄nAChRCalcium ChannelEndogenous MetaboliteNicotinic acetylcholine receptorsCa2+ channelsCa channelsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Acetylcholine-d4 chloride (Synonyms: ACh-d4 (chloride))

Customer Review

Other Forms of Acetylcholine-d4 chloride:

Acetylcholine-d4 chloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Acetylcholine-d4 chloride Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Acetylcholine-d4 chloride Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report

Acetylcholine-d₄ chloride (Synonyms: ACh-d₄ (chloride))

Other Forms of Acetylcholine-d₄ chloride:

Acetylcholine-d₄ chloride Related Antibodies

Acetylcholine-d₄ chloride Related Antibodies

Acetylcholine-d₄ chloride Related Classifications