2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-10

AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE.

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AChE-IN-10 Chemical Structure

AChE-IN-10 Chemical Structure

CAS No. : 2770832-90-9

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AChE-IN-10 Related Antibodies

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Description

AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE[1].

IC50 & Target

AChE

 

Molecular Weight

451.53

Formula

C23H27F2NO4S
CAS No.
SMILES

COC1=C(C=C2C(CC(CC3CCN(CC3)CC4=CC=CC(F)=C4)(S2(=O)=O)F)=C1)OC
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Purity & Documentation
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AChE-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-102770832-90-9Cholinesterase (ChE)AChEtau phosphorylationneuroprotectionneuronal morphologycell viabilityamyloid aggregationInhibitorinhibitorinhibit

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