Actinomycin X2  (Synonyms: Actinomycin V)

Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection^[1][2].

Actinomycin X2 (1, 10 μM, 24 h) 通过 mTOR 途径联合 MiRNA144 诱导人前列腺癌细胞凋亡^[2]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1269.40

C₆₂H₈₄N₁₂O₁₇

18865-48-0

Solid

Orange to red

O=C(N[C@H](C(N[C@H](C(C)C)C(N([C@@]([H])(C1)C2=O)CC1=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN2C)=O)=O)C(C3=NC4=C(C(N[C@H](C(N[C@H](C(C)C)C(N5[C@@]([H])(CCC5)C6=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN6C)=O)=O)=O)C=CC(C)=C4OC3=C7C)=C(N)C7=O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.  [Content Brief]

  [2]. Liu J, et al. Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144. Anticancer Drugs. 2016 Mar;27(3):156-63.  [Content Brief]