Adenosine 5'-triphosphate-¹³C₁₀,¹⁵N₅ dilithium 

Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation^{[1][2][3][4][5]}.

533.94

¹³C₁₀H₁₄Li₂¹⁵N₅O₁₃P₃

Liquid

Colorless to light yellow

OP(OP(OP(O[13CH2][13C@H]1O[13C@H]([13C@@H]([13C@@H]1O)O)[15N]2[13C]3=[13C]([15N]=[13CH]2)[13C]([15NH2])=[15N][13CH]=[15N]3)(O[Li])=O)(O[Li])=O)(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.  [Content Brief]

  [3]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.  [Content Brief]

  [4]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.  [Content Brief]

  [5]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.  [Content Brief]