2. Anti-infection
  3. SARS-CoV
  4. Adintrevimab

Adintrevimab  (Synonyms: ADG 20)

Cat. No.: HY-P99423 Purity: 96.94%
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Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential.

For research use only. We do not sell to patients.

CAS No. : 2516243-54-0

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Based on 1 publication(s) in Google Scholar

Adintrevimab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Adintrevimab

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Description

Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. Adintrevimab inhibits SARS-CoV-2 variants and other SARS-like coronaviruses with pandemic potential[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
In Vitro

The crystallizable fragment (Fc) region of Adintrevimab has a modification to extend its half-life. Adintrevimab binds to a distinct epitope in the receptor-binding domain of the spike glycoprotein of SARS-CoV-2 that partially overlaps the angiotensin-converting enzyme 2 binding site and is highly conserved among sarbecoviruses. In vitro, Adintrevimab has demonstrated potent neutralizing activity against most variants and sublineages of SARS-CoV-2 (including Alpha, Beta, Gamma, and Delta) as well as other SARS-like viruses. Adintrevimab displays reduced in vitro activity against Omicron BA.1/BA.1.1 and lacks activity against BA.2, BA.3, BA.4, and BA.5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adintrevimab Related Antibodies
In Vivo

Adintrevimab (9.25, 55, 333, or 2,000 μg; i.p.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner[1].
Adintrevimab (5-25 mg/kg; i.v.; once) provids protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syrian golden hamsters (5-6-week-old females; 75-125 g) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 9.25, 55, 333, or 2,000 μg (average range: 0.1 to 20 mg/kg)
Administration: Intraperitoneal injection; single dose
Result: Showed significant reduction in lung viral load and virus-induced lung pathology.
Animal Model: Rhesus macaques (5.6-8.8 years old; 6 females [4.4-6.3 kg] and 6 males [6.1-8.5 kg]) infected with SARS-CoV-2/WA1/2020[1].
Dosage: 5 mg/kg, 25 mg/kg
Administration: Intravenous injection; single dose
Result: Reduced pulmonary inflammation.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Adintrevimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation
References
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Adintrevimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adintrevimab2516243-54-0ADG 20ADG20ADG-20SARS-CoVSARS coronavirusSARS-CoV-2human IgG1 monoclonalInhibitorinhibitorinhibit

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