Adoprazine hydrochloride  (Synonyms: SLV313 hydrochloride)

Adoprazine (SLV313) hydrochloride is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine hydrochloride is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics^[1].

Adoprazine hydrochloride has high affinity at human recombinant D₂, D₃, D₄, 5-HT_2B, and 5-HT_1A receptors, with pK_is of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively^[1].
Adoprazine hydrochloride acts as a high potency dopamine D₂ receptor antagonist and an efficacious serotonin 5-HT_1A receptor agonist, with E_max value (% effect of 10 μM 5-HT) of 73 and pK_B value of 8.5 ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adoprazine (0.1-10 mg/kg; p.o.; single) hydrochloride is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

441.93

C₂₄H₂₅ClFN₃O₂

222551-05-5

FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsych  [Content Brief]

  [2]. Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70.  [Content Brief]