2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor Adenylate Cyclase
  4. ADX-10061

ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia.

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ADX-10061 Chemical Structure

ADX-10061 Chemical Structure

CAS No. : 128022-68-4

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ADX-10061 Related Antibodies

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Description

ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia[1].

IC50 & Target

D1 Receptor

5.8 nM (Ki)

D2 Receptor

> ＞10 000 nM (Ki)

Molecular Weight

340.37

Formula

C19H20N2O4
CAS No.
SMILES

OC1=C([N+]([O-])=O)C=C2CCN(C)C[C@H](C3=C(OCC4)C4=CC=C3)C2=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADX-10061 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADX-10061128022-68-4CEE 03-310 NNC 687ADX10061ADX 10061NNC687NNC 687NNC-687Dopamine ReceptorAdenylate CyclaseAdenylyl cyclaseschizophreniaInhibitorinhibitorinhibit

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