AE-ITU dihydrobromide

Cat. No.: HY-131929 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats.

For research use only. We do not sell to patients.

AE-ITU dihydrobromide Chemical Structure

CAS No. : 56-10-0

Size	Price	Stock	Quantity
100 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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nNOS iNOS eNOS

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

iNOS

In Vivo

AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	LPS (HY-D1056)-administrated Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	i.v., 1 mg/kg/h for 1 hour
Result:	Reduced the serum levels of bilirubin, serum nitrite, GOT, GPT and γGT caused by LPS, inhibited iNOS in lung and liver homogenates.

Molecular Weight

281.01

Formula

C₃H₁₁Br₂N₃S

CAS No.

56-10-0

Appearance

Solid

Color

White to yellow

SMILES

NC(SCCN)=N.[H]Br.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (355.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5586 mL	17.7930 mL	35.5859 mL
5 mM	0.7117 mL	3.5586 mL	7.1172 mL
10 mM	0.3559 mL	1.7793 mL	3.5586 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (270 KB) SDS (393 KB)

COA (244 KB) HNMR (118 KB)

Handling Instructions (2659 KB)

References

[1]. Thiemermann C, et al., The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol. 1995 Dec;116(7):2845-51. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.5586 mL	17.7930 mL	35.5859 mL	88.9648 mL
	5 mM	0.7117 mL	3.5586 mL	7.1172 mL	17.7930 mL
	10 mM	0.3559 mL	1.7793 mL	3.5586 mL	8.8965 mL
	15 mM	0.2372 mL	1.1862 mL	2.3724 mL	5.9310 mL
	20 mM	0.1779 mL	0.8896 mL	1.7793 mL	4.4482 mL
	25 mM	0.1423 mL	0.7117 mL	1.4234 mL	3.5586 mL
	30 mM	0.1186 mL	0.5931 mL	1.1862 mL	2.9655 mL
	40 mM	0.0890 mL	0.4448 mL	0.8896 mL	2.2241 mL
	50 mM	0.0712 mL	0.3559 mL	0.7117 mL	1.7793 mL
	60 mM	0.0593 mL	0.2965 mL	0.5931 mL	1.4827 mL
	80 mM	0.0445 mL	0.2224 mL	0.4448 mL	1.1121 mL
	100 mM	0.0356 mL	0.1779 mL	0.3559 mL	0.8896 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.