2. Immunology/Inflammation
  3. NO Synthase
  4. AE-ITU dihydrobromide

AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats.

For research use only. We do not sell to patients.

AE-ITU dihydrobromide Chemical Structure

AE-ITU dihydrobromide Chemical Structure

CAS No. : 56-10-0

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AE-ITU dihydrobromide Related Antibodies

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Description

AE-ITU dihydrobromide is the dihydrobromide form of AE-ITU. AE-ITU dihydrobromide is a selective inhibitor for inducible NO synthase (iNOS), and attenuates the liver dysfunction caused by endotoxaemia in rats[1].

IC50 & Target

iNOS

 

In Vivo

AE-ITU dihydrobromide (1 mg/kg/h, i.v., for 1 hour) attenuates the delayed hypotension and vascular hyporeactivity, ameliorates liver dysfunction in LPS (HY-D1056)-administrated Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS (HY-D1056)-administrated Wistar rats[1]
Dosage: 1 mg/kg
Administration: i.v., 1 mg/kg/h for 1 hour
Result: Reduced the serum levels of bilirubin, serum nitrite, GOT, GPT and γGT caused by LPS, inhibited iNOS in lung and liver homogenates.
Molecular Weight

281.01

Formula

C3H11Br2N3S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NC(SCCN)=N.[H]Br.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (355.86 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5586 mL 17.7930 mL 35.5859 mL
5 mM 0.7117 mL 3.5586 mL 7.1172 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB) HNMR (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5586 mL 17.7930 mL 35.5859 mL 88.9648 mL
5 mM 0.7117 mL 3.5586 mL 7.1172 mL 17.7930 mL
10 mM 0.3559 mL 1.7793 mL 3.5586 mL 8.8965 mL
15 mM 0.2372 mL 1.1862 mL 2.3724 mL 5.9310 mL
20 mM 0.1779 mL 0.8896 mL 1.7793 mL 4.4482 mL
25 mM 0.1423 mL 0.7117 mL 1.4234 mL 3.5586 mL
30 mM 0.1186 mL 0.5931 mL 1.1862 mL 2.9655 mL
40 mM 0.0890 mL 0.4448 mL 0.8896 mL 2.2241 mL
50 mM 0.0712 mL 0.3559 mL 0.7117 mL 1.7793 mL
60 mM 0.0593 mL 0.2965 mL 0.5931 mL 1.4827 mL
80 mM 0.0445 mL 0.2224 mL 0.4448 mL 1.1121 mL
100 mM 0.0356 mL 0.1779 mL 0.3559 mL 0.8896 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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AE-ITU dihydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AE-ITU dihydrobromide56-10-0NO SynthaseNitric oxide synthasesNOSWistar ratsInhibitorinhibitorinhibit

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