Aerothionin

Cat. No.: HY-121349: FAQs
Data Sheet Handling Instructions Technical Support

Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs).

For research use only. We do not sell to patients.

Aerothionin Chemical Structure

CAS No. : 28714-26-3

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	> 10 μg/mL Compound: 4	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17512741]
HeLa	IC₅₀	29 μM Compound: 2	Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay	[PMID: 33940466]
HT-29	GI₅₀	> 10 μg/mL Compound: 4	Cytotoxicity against human HT29 cells by SRB assay Cytotoxicity against human HT29 cells by SRB assay	[PMID: 17512741]
MDA-MB-231	GI₅₀	> 10 μg/mL Compound: 4	Cytotoxicity against human MDA-MB-231 cells by SRB assay Cytotoxicity against human MDA-MB-231 cells by SRB assay	[PMID: 17512741]

In Vitro

Aerothionin (0-100 μM, 24h) inhibits prolifeartions of pheochromocytoma cells MPC and MTT, inhibits the MTT spheroid growth (10 μM, single dose)^[1].
Aerothionin (0-100 μM, 24h) exhibits toxicity in normal endothelial cells HUVECs, stimulates slightly the viability of normal fibroblasts 3T3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MPC, MTT, HUVECs, 3T3
Concentration:	0-100 μM
Incubation Time:	24 h
Result:	Inhibited proliferations of MPC, MTT and HUVECs, stimulated proliferation of 32T3.

Molecular Weight

818.10

Formula

C₂₄H₂₆Br₄N₄O₈

CAS No.

28714-26-3

SMILES

O[C@@H]1[C@@]2(C=C(C(OC)=C1Br)Br)CC(C(NCCCCNC(C3=NO[C@@]4([C@H](C(Br)=C(C(Br)=C4)OC)O)C3)=O)=O)=NO2

Structure Classification

Antibiotics

Initial Source

Aplysina fistularis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Drechsel A, et al., Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro. Mar Drugs. 2020 May 1;18(5):236. [Content Brief]

[2]. Šimovičová M. Synthesis of aerothionin analogs as potential antimycobacterial agents[J]. 2021.

Aerothionin Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aerothionin28714-26-3BacterialFungalAntibioticHUVECs3T3MPCMTTextra-adrenal paragangliomasPPGLInhibitorinhibitorinhibit

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