2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. AF-DX 384

AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively). AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine.

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AF-DX 384 Chemical Structure

AF-DX 384 Chemical Structure

CAS No. : 118290-26-9

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Based on 1 publication(s) in Google Scholar

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AF-DX 384 Related Antibodies

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Description

AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].

Molecular Weight

478.63

Formula

C27H38N6O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=CC=CN=C2N(C3=C1C=CC=C3)C(NCCN4CCCCC4CN(CCC)CCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 98.0%

SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References
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AF-DX 384 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AF-DX 384118290-26-9mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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