AG6033

Cat. No.: HY-143435: FAQs
Data Sheet Handling Instructions

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AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect.

For research use only. We do not sell to patients.

AG6033 Chemical Structure

CAS No. : 329706-62-9

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Biological Activity
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Description

IC₅₀ & Target

CRBN

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.853 μM Compound: AG6033	Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay	[PMID: 35413617]

In Vitro

AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549^[1].
AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549 cells^[1]
Concentration:	0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM
Incubation Time:	4 h
Result:	Exhibited potent inhibitory ability against A549, with an IC₅₀ of 0.853 μM.

Apoptosis Analysis

Cell Line:	A549 cells^[1]
Concentration:	1 μM, 5 μM, 10 μM
Incubation Time:	24 h
Result:	Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.

Molecular Weight

517.53

Formula

C₃₀H₂₃N₅O₄

CAS No.

329706-62-9

SMILES

O=C(N/N=C1C(N(CC(NC2=CC=CC=C2)=O)C3=C\1C=CC=C3)=O)C4=CC=CC(NC(C5=CC=CC=C5)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiong F, Kong L, Chen L, et al. Discovery of potential novel CRBN modulators by virtual screening and bioassay. Eur J Med Chem. 2022 Apr 5;236:114355. [Content Brief]

AG6033 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG6033329706-62-9AG 6033AG-6033ApoptosisMultiple myelomaA549 cellsAntitumorApoptosis assayWestern blot analysisMolecular dockingInhibitorinhibitorinhibit

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