2. Signaling Pathways
  3. Immunology/Inflammation
  4. IKZF Family
  5. IKZF1 Isoform

IKZF1

 

IKZF1 Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-145776
    ALV1
    		Inhibitor
    ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds CRBN with an IC50 of 0.55 µM. ALV1 induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of Treg cells.
  • HY-168615
    MGD-28
    		Degrader
    MGD-28 is a potent, orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. In addition, MGD-4 also degrades CK1α (DC50=7.8 nM). MGD-28 has antiproliferative activity and can be used in multiple myeloma research.
  • HY-168614
    MGD-4
    		Degrader
    MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma.
  • HY-160531
    IKZF1-degrader-1
    		Degrader
    IKZF1-degrader-1 (Compound 9-B) is a IKZF1 molecular glue degrader with the DC50 value of 0.134 nM. IKZF1-degrader-1 can be used to degrader tumors.