2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. Aurora Kinase JAK STAT
  4. AJI-214

AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD).

For research use only. We do not sell to patients.

AJI-214 Chemical Structure

AJI-214 Chemical Structure

CAS No. : 1395886-20-0

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AJI-214 Related Antibodies

Top Publications Citing Use of Products

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Aurora Kinase Aurora A Aurora B Aurora C

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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Description

AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD)[1].

Molecular Weight

357.77

Formula

C17H13ClFN5O
CAS No.
SMILES

O=C(C1=CC=C(NC2=NC=C(C(NC3=C(Cl)C=CC=C3)=N2)F)C=C1)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AJI-214 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AJI-2141395886-20-0AJI214AJI 214Aurora KinaseJAKSTATJanus kinaseDual-target inhibitorsT cellsmitosiscell differentiationphosphorylationGVHDInhibitorinhibitorinhibit

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