2. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  3. Prostaglandin Receptor p38 MAPK ERK
  4. AL-8810

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG).

For research use only. We do not sell to patients.

AL-8810 Chemical Structure

AL-8810 Chemical Structure

CAS No. : 246246-19-5

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Based on 1 publication(s) in Google Scholar

Other Forms of AL-8810:

AL-8810 Related Antibodies

Top Publications Citing Use of Products

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DP EP FP IP TXA2/TP TXB2

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)[1][2][3][4][5].

In Vitro

AL-8810 (0.1, 1, 10 μM, 24 h) can significantly reduce the neuronal cell death of WT mice after OGD-induced injury[2].
AL-8810 (1, 10 μM, 24 h) promotes the activation of ERK1/2 in HEK 293 and MG-63 cells through epidermal growth factor receptor deactivation mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AL-8810 Related Antibodies

Western Blot Analysis[3]

Cell Line: HEK 293, MG-63
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Activated ERK1/2 and MAPK.
Activated MAPK through EGFR transactivation.
In Vivo

AL-8810 (1 or 10 mg/kg, intravenously) reduces ischemic brain injury and neurotoxicity in mice[2].
AL-8810 (10 mg/kg, intraperitoneal injection) can improve the prognosis after experimental traumatic brain injury in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Stroke mouse model[2]
Dosage: 1 or 10 mg/kg
Administration: i.v.
Result: Reduced the cortical infarct volume and tape-removal times.
Animal Model: Traumatic brain injury (TBI) model[5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Improved neurological deficit scores (NDS) at 24 and 48 hours after controlled cortical impact (CCI).
Molecular Weight

402.50

Formula

C24H31FO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](C2CC3=C(C=CC=C3)C2)O)[C@@H](F)C[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (24.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4845 mL 12.4224 mL 24.8447 mL
5 mM 0.4969 mL 2.4845 mL 4.9689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4845 mL 12.4224 mL 24.8447 mL 62.1118 mL
5 mM 0.4969 mL 2.4845 mL 4.9689 mL 12.4224 mL
10 mM 0.2484 mL 1.2422 mL 2.4845 mL 6.2112 mL
15 mM 0.1656 mL 0.8282 mL 1.6563 mL 4.1408 mL
20 mM 0.1242 mL 0.6211 mL 1.2422 mL 3.1056 mL
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AL-8810 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-8810246246-19-5AL8810AL 8810Prostaglandin Receptorp38 MAPKERKExtracellular signal regulated kinasesHEK 293MG-63Traumatic brain injuryStokeInhibitorinhibitorinhibit

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