AL-9

Cat. No.: HY-118525 Purity: 99.68%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

AL-9 is a inhibitor of PI4KIIIα, with the IC₅₀ of 0.57 μM, that can inhibit HCV replication.

For research use only. We do not sell to patients.

AL-9 Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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PI4KIIIβ PI4KIIIα PI4K PI4KII

Biological Activity
Purity & Documentation
References
Customer Review

Description

AL-9 is a inhibitor of PI4KIIIα, with the IC₅₀ of 0.57 μM, that can inhibit HCV replication^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.29 μM Compound: AL-9	Antiviral activity against HCV genotype 1b infected in human Huh7.5 cells assessed as inhibition of viral replication after 72 hrs by real time PCR analysis Antiviral activity against HCV genotype 1b infected in human Huh7.5 cells assessed as inhibition of viral replication after 72 hrs by real time PCR analysis	[PMID: 24900715]
Sf9	IC₅₀	0.57 μM Compound: AL-9	Inhibition of PI4K3alpha catalytic domain (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay Inhibition of PI4K3alpha catalytic domain (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay	[PMID: 24900715]
Sf9	IC₅₀	3.08 μM Compound: AL-9	Inhibition of PI4K3beta (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay Inhibition of PI4K3beta (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay	[PMID: 24900715]

Molecular Weight

402.45

Formula

C₂₃H₂₂N₄O₃

CAS No.

869218-90-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC1=CC=C(C2=CC3=C(NC4=CC=C(N5CCOCC5)C=C4)N=CN=C3C=C2)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (12.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4848 mL	12.4239 mL	24.8478 mL
5 mM	0.4970 mL	2.4848 mL	4.9696 mL
10 mM	0.2485 mL	1.2424 mL	2.4848 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (248 KB) HNMR (258 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Annalisa Bianco, et al. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. PLoS Pathog. 2012;8(3):e1002576. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4848 mL	12.4239 mL	24.8478 mL	62.1195 mL
	5 mM	0.4970 mL	2.4848 mL	4.9696 mL	12.4239 mL
	10 mM	0.2485 mL	1.2424 mL	2.4848 mL	6.2120 mL

AL-9 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-9869218-90-6AL9AL 9HCVPI4KHepatitis C virusPhosphatidylinositol 4 kinasesPI4 kinasesPI4KIIIα/HCV InhibitorInhibitorinhibitorinhibit

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AL-9

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