2. Anti-infection
  3. HBV
  4. Alamifovir

Alamifovir  (Synonyms: LY582563; MCC-478)

Cat. No.: HY-119691 Purity: ≥95.0%
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Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect.

For research use only. We do not sell to patients.

Alamifovir Chemical Structure

Alamifovir Chemical Structure

CAS No. : 193681-12-8

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1 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

Alamifovir Related Antibodies

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Description

Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].

In Vitro

MCC-478 (0-10 μM) has EC50s of 0.027 μM for wild-type HBV, 2.6 μM for M552I, 3.3 μM for M552V, and 2.0 μM for L528M/M552V[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alamifovir Related Antibodies
Molecular Weight

575.42

Formula

C19H20F6N5O5PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C=C1)SC2=C3N=CN(C3=NC(N)=N2)CCOCP(OCC(F)(F)F)(OCC(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.75 mg/mL (9.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7379 mL 8.6893 mL 17.3786 mL
5 mM 0.3476 mL 1.7379 mL 3.4757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7379 mL 8.6893 mL 17.3786 mL 43.4465 mL
5 mM 0.3476 mL 1.7379 mL 3.4757 mL 8.6893 mL
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Alamifovir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alamifovir193681-12-8LY582563 MCC-478LY 582563LY-582563MCC478MCC 478MCC-478HBVHepatitis B viruspurine nucleotideprodruglamivudinehepatitis B virusantiviralInhibitorinhibitorinhibit

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