2. PROTAC
  3. PROTAC Linkers
  4. Ald-Ph-amido-PEG2-C2-Boc

Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Ald-Ph-amido-PEG2-C2-Boc Chemical Structure

Ald-Ph-amido-PEG2-C2-Boc Chemical Structure

CAS No. : 1807521-09-0

Size Price Stock Quantity
25 mg USD 75 In-stock
50 mg USD 120 In-stock
100 mg USD 180 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Ald-Ph-amido-PEG2-C2-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ald-Ph-amido-PEG2-C2-Boc Related Antibodies
Molecular Weight

365.42

Formula

C19H27NO6
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCNC(C1=CC=C(C=O)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (273.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7366 mL 13.6829 mL 27.3658 mL
5 mM 0.5473 mL 2.7366 mL 5.4732 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7366 mL 13.6829 mL 27.3658 mL 68.4144 mL
5 mM 0.5473 mL 2.7366 mL 5.4732 mL 13.6829 mL
10 mM 0.2737 mL 1.3683 mL 2.7366 mL 6.8414 mL
15 mM 0.1824 mL 0.9122 mL 1.8244 mL 4.5610 mL
20 mM 0.1368 mL 0.6841 mL 1.3683 mL 3.4207 mL
25 mM 0.1095 mL 0.5473 mL 1.0946 mL 2.7366 mL
30 mM 0.0912 mL 0.4561 mL 0.9122 mL 2.2805 mL
40 mM 0.0684 mL 0.3421 mL 0.6841 mL 1.7104 mL
50 mM 0.0547 mL 0.2737 mL 0.5473 mL 1.3683 mL
60 mM 0.0456 mL 0.2280 mL 0.4561 mL 1.1402 mL
80 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
100 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6841 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Ald-Ph-amido-PEG2-C2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ald-Ph-amido-PEG2-C2-Boc1807521-09-0PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ald-Ph-amido-PEG2-C2-Boc
Cat. No.:
HY-130202
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.