Aldosterone-d₇

Name: Aldosterone-d 7
Brand: MedChemExpress
SKU: HY-113313S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-113313S1 Purity: 98.64%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aldosterone-d₇ is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

For research use only. We do not sell to patients.

Aldosterone-d<sub>7</sub> Chemical Structure

Aldosterone-d₇ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 2780	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Aldosterone-d₇:

Aldosterone Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.49

Formula

C₂₁H₂₁D₇O₅

Unlabeled CAS

52-39-1

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(C([2H])([2H])O)=O)CC[C@@]4([H])[C@]3([H])CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 33.33 mg/mL (90.70 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7212 mL	13.6058 mL	27.2116 mL
5 mM	0.5442 mL	2.7212 mL	5.4423 mL
10 mM	0.2721 mL	1.3606 mL	2.7212 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (258 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. [Content Brief]

[3]. Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598. [Content Brief]

[4]. Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73. [Content Brief]

[5]. Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104. [Content Brief]

[6]. Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / Ethanol / DMSO / DMSO	1 mM	2.7212 mL	13.6058 mL	27.2116 mL	68.0291 mL
	5 mM	0.5442 mL	2.7212 mL	5.4423 mL	13.6058 mL
	10 mM	0.2721 mL	1.3606 mL	2.7212 mL	6.8029 mL
	15 mM	0.1814 mL	0.9071 mL	1.8141 mL	4.5353 mL
	20 mM	0.1361 mL	0.6803 mL	1.3606 mL	3.4015 mL
	25 mM	0.1088 mL	0.5442 mL	1.0885 mL	2.7212 mL
	30 mM	0.0907 mL	0.4535 mL	0.9071 mL	2.2676 mL
	40 mM	0.0680 mL	0.3401 mL	0.6803 mL	1.7007 mL
	50 mM	0.0544 mL	0.2721 mL	0.5442 mL	1.3606 mL
	60 mM	0.0454 mL	0.2268 mL	0.4535 mL	1.1338 mL
	80 mM	0.0340 mL	0.1701 mL	0.3401 mL	0.8504 mL
DMSO / DMSO	100 mM	0.0272 mL	0.1361 mL	0.2721 mL	0.6803 mL