1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Aldosterone-d7

Aldosterone-d7 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

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Aldosterone-d<sub>7</sub> Chemical Structure

Aldosterone-d7 Chemical Structure

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1 mg USD 2780 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Aldosterone-d7:

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Description

Aldosterone-d7 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.49

Formula

C21H21D7O5

Unlabeled CAS

52-39-1

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(C([2H])([2H])O)=O)CC[C@@]4([H])[C@]3([H])CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (272.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (272.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 33.33 mg/mL (90.70 mM; Need ultrasonic)

Ethanol : 33.33 mg/mL (90.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7212 mL 13.6058 mL 27.2116 mL
5 mM 0.5442 mL 2.7212 mL 5.4423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMSO / DMSO 1 mM 2.7212 mL 13.6058 mL 27.2116 mL 68.0291 mL
5 mM 0.5442 mL 2.7212 mL 5.4423 mL 13.6058 mL
10 mM 0.2721 mL 1.3606 mL 2.7212 mL 6.8029 mL
15 mM 0.1814 mL 0.9071 mL 1.8141 mL 4.5353 mL
20 mM 0.1361 mL 0.6803 mL 1.3606 mL 3.4015 mL
25 mM 0.1088 mL 0.5442 mL 1.0885 mL 2.7212 mL
30 mM 0.0907 mL 0.4535 mL 0.9071 mL 2.2676 mL
40 mM 0.0680 mL 0.3401 mL 0.6803 mL 1.7007 mL
50 mM 0.0544 mL 0.2721 mL 0.5442 mL 1.3606 mL
60 mM 0.0454 mL 0.2268 mL 0.4535 mL 1.1338 mL
80 mM 0.0340 mL 0.1701 mL 0.3401 mL 0.8504 mL
DMSO / DMSO 100 mM 0.0272 mL 0.1361 mL 0.2721 mL 0.6803 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Aldosterone-d7
Cat. No.:
HY-113313S1
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