2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. ALKBH5-IN-3

ALKBH5-IN-3 (Compound 20m) is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells.

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ALKBH5-IN-3 Chemical Structure

ALKBH5-IN-3 Chemical Structure

CAS No. : 1505579-77-0

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Based on 1 publication(s) in Google Scholar

ALKBH5-IN-3 Related Antibodies

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Description

ALKBH5-IN-3 (Compound 20m) is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells[1].

IC50 & Target

IC50: 21 nM (ALKBH5)[1]
Molecular Weight

272.18

Formula

C11H7F3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(C2=CC=CC(C(F)(F)F)=C2)C(O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (114.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6740 mL 18.3702 mL 36.7404 mL
5 mM 0.7348 mL 3.6740 mL 7.3481 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6740 mL 18.3702 mL 36.7404 mL 91.8510 mL
5 mM 0.7348 mL 3.6740 mL 7.3481 mL 18.3702 mL
10 mM 0.3674 mL 1.8370 mL 3.6740 mL 9.1851 mL
15 mM 0.2449 mL 1.2247 mL 2.4494 mL 6.1234 mL
20 mM 0.1837 mL 0.9185 mL 1.8370 mL 4.5925 mL
25 mM 0.1470 mL 0.7348 mL 1.4696 mL 3.6740 mL
30 mM 0.1225 mL 0.6123 mL 1.2247 mL 3.0617 mL
40 mM 0.0919 mL 0.4593 mL 0.9185 mL 2.2963 mL
50 mM 0.0735 mL 0.3674 mL 0.7348 mL 1.8370 mL
60 mM 0.0612 mL 0.3062 mL 0.6123 mL 1.5308 mL
80 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1481 mL
100 mM 0.0367 mL 0.1837 mL 0.3674 mL 0.9185 mL
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ALKBH5-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALKBH5-IN-31505579-77-0Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246ALKBH5m6AInhibitorinhibitorinhibit

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