2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. Alternaphenol B2

Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 μM.

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Alternaphenol B2 Chemical Structure

Alternaphenol B2 Chemical Structure

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Alternaphenol B2 Related Antibodies

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Description

Alternaphenol B2 is a selective IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Alternaphenol B2 shows inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC50 values of 41.9 μM[1].

IC50 & Target

41.9 μM[1]
Molecular Weight

286.24

Formula

C15H10O6
SMILES

OC1=C(C(C(OC2=C3C(O)=CC(CO)=C2)=O)=CC=C1)C3=O
Structure Classification
Initial Source

Parengyodontium album
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Alternaphenol B2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alternaphenol B2Alternaphenol B 2Alternaphenol B-2Isocitrate Dehydrogenase (IDH)Coral derived fungusisocitrate dehydrogenasepolyketidesecondary metabolitesInhibitorinhibitorinhibit

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