2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. ALX-1393 TFA

ALX-1393 TFA, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.

For research use only. We do not sell to patients.

ALX-1393 TFA Chemical Structure

ALX-1393 TFA Chemical Structure

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1 mg USD 150 In-stock
5 mg USD 450 In-stock
10 mg USD 700 In-stock
25 mg USD 1480 In-stock
50 mg USD 2550 In-stock
100 mg USD 4500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ALX-1393 TFA:

ALX-1393 TFA Related Antibodies

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GlyT1 GlyT2

  • Biological Activity

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Description

ALX-1393 TFA, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

In Vitro

ALX1393 TFA (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALX-1393 TFA Related Antibodies
Molecular Weight

509.45

Formula

C25H23F4NO6
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COC(C1=CC=CC(F)=C1)C2=CC=CC=C2OCC3=CC=CC=C3)C(O)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9629 mL 9.8145 mL 19.6290 mL
5 mM 0.3926 mL 1.9629 mL 3.9258 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9629 mL 9.8145 mL 19.6290 mL 49.0725 mL
5 mM 0.3926 mL 1.9629 mL 3.9258 mL 9.8145 mL
10 mM 0.1963 mL 0.9815 mL 1.9629 mL 4.9073 mL
15 mM 0.1309 mL 0.6543 mL 1.3086 mL 3.2715 mL
20 mM 0.0981 mL 0.4907 mL 0.9815 mL 2.4536 mL
25 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9629 mL
30 mM 0.0654 mL 0.3272 mL 0.6543 mL 1.6358 mL
40 mM 0.0491 mL 0.2454 mL 0.4907 mL 1.2268 mL
50 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
60 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8179 mL
80 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6134 mL
100 mM 0.0196 mL 0.0981 mL 0.1963 mL 0.4907 mL
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ALX-1393 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALX-1393ALX1393ALX 1393GlyTGlycine transportersInhibitorinhibitorinhibit

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