2. PI3K/Akt/mTOR
  3. PI3K
  4. AM-0687

AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy.

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AM-0687 Chemical Structure

AM-0687 Chemical Structure

CAS No. : 1259522-94-5

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AM-0687 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

AM-0687 is a selective inhibitor for PI3Kδ with an IC50 of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC50=0.8 nM) and the phosphorylation of AKT (IC50=0.7 nM), and exhibits anti-inflammatory efficacy[1].

IC50 & Target

PI3Kδ

2.9 nM (IC50)

PI3Kβ

2840 nM (IC50)

PI3Kγ

3530 nM (IC50)

PI3Kα

17600 nM (IC50)

Molecular Weight

442.45

Formula

C23H19FN8O
CAS No.
SMILES

O=C(C1=C(C2=NC=CC=C2)C([C@@H](NC3=NC=NC(N)=C3C#N)C)=NC4=CC=C(F)C=C14)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM-0687 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-06871259522-94-5AM0687AM 0687PI3KPhosphoinositide 3-kinaseselectiveanti-inflammatoryInhibitorinhibitorinhibit

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