AM-Imidazole-PA-Boc

Name: AM-Imidazole-PA-Boc
Brand: MedChemExpress
SKU: HY-129968
Rating: 4.5 (1 reviews)

Cat. No.: HY-129968 Purity: 98.22%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966).

For research use only. We do not sell to patients.

AM-Imidazole-PA-Boc Chemical Structure

CAS No. : 2357108-99-5

Size	Price	Stock	Quantity
25 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 98	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 158	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
1 g	USD 520	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AM-Imidazole-PA-Boc is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966)^[1].

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.33

Formula

C₁₂H₂₂N₄O₂

CAS No.

2357108-99-5

Appearance

Oil

Color

Off-white to gray

SMILES

NCC1=CN(CCCNC(OC(C)(C)C)=O)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (393.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9319 mL	19.6595 mL	39.3190 mL
5 mM	0.7864 mL	3.9319 mL	7.8638 mL
10 mM	0.3932 mL	1.9659 mL	3.9319 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.22%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (243 KB) HNMR (179 KB) LCMS (75 KB)

Handling Instructions (2659 KB)

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9319 mL	19.6595 mL	39.3190 mL	98.2975 mL
	5 mM	0.7864 mL	3.9319 mL	7.8638 mL	19.6595 mL
	10 mM	0.3932 mL	1.9659 mL	3.9319 mL	9.8297 mL
	15 mM	0.2621 mL	1.3106 mL	2.6213 mL	6.5532 mL
	20 mM	0.1966 mL	0.9830 mL	1.9659 mL	4.9149 mL
	25 mM	0.1573 mL	0.7864 mL	1.5728 mL	3.9319 mL
	30 mM	0.1311 mL	0.6553 mL	1.3106 mL	3.2766 mL
	40 mM	0.0983 mL	0.4915 mL	0.9830 mL	2.4574 mL
	50 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9659 mL
	60 mM	0.0655 mL	0.3277 mL	0.6553 mL	1.6383 mL
	80 mM	0.0491 mL	0.2457 mL	0.4915 mL	1.2287 mL
	100 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9830 mL