Amine-PEG6-thiol hydrochloride

Cat. No.: HY-134711A: FAQs
Data Sheet Handling Instructions Technical Support

Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amine-PEG6-thiol hydrochloride Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of Amine-PEG6-thiol hydrochloride:

Amine-PEG6-thiol Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.92

Formula

C₁₄H₃₂ClNO₆S

Appearance

Viscous Liquid

SMILES

SCCOCCOCCOCCOCCOCCOCCN.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 350 mg/mL (926.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6461 mL	13.2303 mL	26.4606 mL
5 mM	0.5292 mL	2.6461 mL	5.2921 mL
10 mM	0.2646 mL	1.3230 mL	2.6461 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6461 mL	13.2303 mL	26.4606 mL	66.1516 mL
	5 mM	0.5292 mL	2.6461 mL	5.2921 mL	13.2303 mL
	10 mM	0.2646 mL	1.3230 mL	2.6461 mL	6.6152 mL
	15 mM	0.1764 mL	0.8820 mL	1.7640 mL	4.4101 mL
	20 mM	0.1323 mL	0.6615 mL	1.3230 mL	3.3076 mL
	25 mM	0.1058 mL	0.5292 mL	1.0584 mL	2.6461 mL
	30 mM	0.0882 mL	0.4410 mL	0.8820 mL	2.2051 mL
	40 mM	0.0662 mL	0.3308 mL	0.6615 mL	1.6538 mL
	50 mM	0.0529 mL	0.2646 mL	0.5292 mL	1.3230 mL
	60 mM	0.0441 mL	0.2205 mL	0.4410 mL	1.1025 mL
	80 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8269 mL
	100 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6615 mL