1. PROTAC
  2. PROTAC Linkers
  3. Amine-PEG6-thiol hydrochloride

Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amine-PEG6-thiol hydrochloride Chemical Structure

Amine-PEG6-thiol hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 126 In-stock
10 mg USD 202 In-stock
25 mg USD 404 In-stock
50 mg USD 646 In-stock
100 mg USD 1029 In-stock
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Other Forms of Amine-PEG6-thiol hydrochloride:

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Description

Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.92

Formula

C14H32ClNO6S

Appearance

Viscous Liquid

SMILES

SCCOCCOCCOCCOCCOCCOCCN.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 350 mg/mL (926.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6461 mL 13.2303 mL 26.4606 mL
5 mM 0.5292 mL 2.6461 mL 5.2921 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6461 mL 13.2303 mL 26.4606 mL 66.1516 mL
5 mM 0.5292 mL 2.6461 mL 5.2921 mL 13.2303 mL
10 mM 0.2646 mL 1.3230 mL 2.6461 mL 6.6152 mL
15 mM 0.1764 mL 0.8820 mL 1.7640 mL 4.4101 mL
20 mM 0.1323 mL 0.6615 mL 1.3230 mL 3.3076 mL
25 mM 0.1058 mL 0.5292 mL 1.0584 mL 2.6461 mL
30 mM 0.0882 mL 0.4410 mL 0.8820 mL 2.2051 mL
40 mM 0.0662 mL 0.3308 mL 0.6615 mL 1.6538 mL
50 mM 0.0529 mL 0.2646 mL 0.5292 mL 1.3230 mL
60 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1025 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8269 mL
100 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6615 mL
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Product Name:
Amine-PEG6-thiol hydrochloride
Cat. No.:
HY-134711A
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