2. PROTAC
  3. PROTAC Linkers
  4. Amino-PEG2-CH2CH2-SH hydrochloride

Amino-PEG2-CH2CH2-SH hydrochloride 

Cat. No.: HY-132120 Purity: ≥95.0%
COA Handling Instructions

Molarity Calculator

Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG2-CH2CH2-SH hydrochloride Chemical Structure

Amino-PEG2-CH2CH2-SH hydrochloride Chemical Structure

CAS No. : 3037676-58-4

Size Price Stock Quantity
5 mg USD 70 In-stock
10 mg USD 115 In-stock
25 mg USD 230 In-stock
50 mg USD 370 In-stock
100 mg USD 595 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Amino-PEG2-CH2CH2-SH hydrochloride Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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Description

Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-PEG2-CH2CH2-SH hydrochloride Related Antibodies
Molecular Weight

201.71

Formula

C6H16ClNO2S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[H]Cl.NCCOCCOCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (619.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9576 mL 24.7881 mL 49.5761 mL
5 mM 0.9915 mL 4.9576 mL 9.9152 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (242 KB) HNMR (139 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9576 mL 24.7881 mL 49.5761 mL 123.9403 mL
5 mM 0.9915 mL 4.9576 mL 9.9152 mL 24.7881 mL
10 mM 0.4958 mL 2.4788 mL 4.9576 mL 12.3940 mL
15 mM 0.3305 mL 1.6525 mL 3.3051 mL 8.2627 mL
20 mM 0.2479 mL 1.2394 mL 2.4788 mL 6.1970 mL
25 mM 0.1983 mL 0.9915 mL 1.9830 mL 4.9576 mL
30 mM 0.1653 mL 0.8263 mL 1.6525 mL 4.1313 mL
40 mM 0.1239 mL 0.6197 mL 1.2394 mL 3.0985 mL
50 mM 0.0992 mL 0.4958 mL 0.9915 mL 2.4788 mL
60 mM 0.0826 mL 0.4131 mL 0.8263 mL 2.0657 mL
80 mM 0.0620 mL 0.3099 mL 0.6197 mL 1.5493 mL
100 mM 0.0496 mL 0.2479 mL 0.4958 mL 1.2394 mL
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Amino-PEG2-CH2CH2-SH hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amino-PEG2-CH2CH2-SH3037676-58-4PROTAC LinkersInhibitorinhibitorinhibit

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