2. PROTAC
  3. PROTAC Linkers
  4. Amino-PEG24-Boc

Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG24-Boc Chemical Structure

Amino-PEG24-Boc Chemical Structure

CAS No. : 2170987-96-7

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25 mg USD 90 In-stock
50 mg USD 145 In-stock
100 mg USD 230 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Amino-PEG24-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-PEG24-Boc Related Antibodies
Molecular Weight

1202.46

Formula

C55H111NO26
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (97.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8316 mL 4.1581 mL 8.3163 mL
5 mM 0.1663 mL 0.8316 mL 1.6633 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8316 mL 4.1581 mL 8.3163 mL 20.7907 mL
5 mM 0.1663 mL 0.8316 mL 1.6633 mL 4.1581 mL
10 mM 0.0832 mL 0.4158 mL 0.8316 mL 2.0791 mL
15 mM 0.0554 mL 0.2772 mL 0.5544 mL 1.3860 mL
20 mM 0.0416 mL 0.2079 mL 0.4158 mL 1.0395 mL
25 mM 0.0333 mL 0.1663 mL 0.3327 mL 0.8316 mL
30 mM 0.0277 mL 0.1386 mL 0.2772 mL 0.6930 mL
40 mM 0.0208 mL 0.1040 mL 0.2079 mL 0.5198 mL
50 mM 0.0166 mL 0.0832 mL 0.1663 mL 0.4158 mL
60 mM 0.0139 mL 0.0693 mL 0.1386 mL 0.3465 mL
80 mM 0.0104 mL 0.0520 mL 0.1040 mL 0.2599 mL
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Amino-PEG24-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amino-PEG24-Boc2170987-96-7PROTAC LinkersInhibitorinhibitorinhibit

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