Amino-PEG3-2G degrader-1

Cat. No.: HY-158985: FAQs
Data Sheet Handling Instructions

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Amino-PEG3-2G degrader-1 (compound ) is a conjugate of a PEG Linker and a pyrazole-linked FBnG tag for ubiquitin-proteasome system (UPS) induction. Amino-PEG3-2G degrader-1 can be used to synthesize autophagy-targeting chimeras (AUTACs).

For research use only. We do not sell to patients.

Amino-PEG3-2G degrader-1 Chemical Structure

CAS No. : 2267315-06-8

Size	Price	Stock
5 mg	USD 380	Ask For Quote & Lead Time
10 mg	USD 610	Ask For Quote & Lead Time
25 mg	USD 1220	Ask For Quote & Lead Time
50 mg	USD 1950	Ask For Quote & Lead Time
100 mg	USD 2950	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Amino-PEG3-2G degrader-1:

Amino-PEG3-2G degrader-1 hydrochloride Get quote

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Purity & Documentation
References
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Description

Molecular Weight

528.58

Formula

C₂₅H₃₃FN₈O₄

CAS No.

2267315-06-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCCOCCOCCOCCCN)N=C4)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (189.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8919 mL	9.4593 mL	18.9186 mL
5 mM	0.3784 mL	1.8919 mL	3.7837 mL
10 mM	0.1892 mL	0.9459 mL	1.8919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takahashi D, et al. Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8919 mL	9.4593 mL	18.9186 mL	47.2965 mL
	5 mM	0.3784 mL	1.8919 mL	3.7837 mL	9.4593 mL
	10 mM	0.1892 mL	0.9459 mL	1.8919 mL	4.7297 mL
	15 mM	0.1261 mL	0.6306 mL	1.2612 mL	3.1531 mL
	20 mM	0.0946 mL	0.4730 mL	0.9459 mL	2.3648 mL
	25 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8919 mL
	30 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5766 mL
	40 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1824 mL
	50 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9459 mL
	60 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
	80 mM	0.0236 mL	0.1182 mL	0.2365 mL	0.5912 mL
	100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.4730 mL