Amino-PEG3-C2-Amine

Name: Amino-PEG3-C2-Amine
Brand: MedChemExpress
SKU: HY-W015088
Rating: 4.5 (1 reviews)

Cat. No.: HY-W015088 Purity: 99.32%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG3-C2-Amine Chemical Structure

CAS No. : 929-75-9

Size	Price	Stock	Quantity
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 70	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

192.26

Formula

C₈H₂₀N₂O₃

CAS No.

929-75-9

Appearance

Liquid (Density: 1.2892 g/cm³)

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (520.13 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2013 mL	26.0065 mL	52.0129 mL
5 mM	1.0403 mL	5.2013 mL	10.4026 mL
10 mM	0.5201 mL	2.6006 mL	5.2013 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (520.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.32%

Select Batch:

Data Sheet (265 KB) SDS (614 KB)

COA (239 KB) RP-HPLC (96 KB)

Handling Instructions (2659 KB)

References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.2013 mL	26.0065 mL	52.0129 mL	130.0323 mL
	5 mM	1.0403 mL	5.2013 mL	10.4026 mL	26.0065 mL
	10 mM	0.5201 mL	2.6006 mL	5.2013 mL	13.0032 mL
	15 mM	0.3468 mL	1.7338 mL	3.4675 mL	8.6688 mL
	20 mM	0.2601 mL	1.3003 mL	2.6006 mL	6.5016 mL
	25 mM	0.2081 mL	1.0403 mL	2.0805 mL	5.2013 mL
	30 mM	0.1734 mL	0.8669 mL	1.7338 mL	4.3344 mL
	40 mM	0.1300 mL	0.6502 mL	1.3003 mL	3.2508 mL
	50 mM	0.1040 mL	0.5201 mL	1.0403 mL	2.6006 mL
	60 mM	0.0867 mL	0.4334 mL	0.8669 mL	2.1672 mL
	80 mM	0.0650 mL	0.3251 mL	0.6502 mL	1.6254 mL
	100 mM	0.0520 mL	0.2601 mL	0.5201 mL	1.3003 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.