2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Amino-PEG4-alcohol

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Amino-PEG4-alcohol Chemical Structure

Amino-PEG4-alcohol Chemical Structure

CAS No. : 86770-74-3

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500 mg USD 40 In-stock
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Based on 1 publication(s) in Google Scholar

Amino-PEG4-alcohol Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1]

PEGs

 

Non-cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-PEG4-alcohol Related Antibodies
Molecular Weight

193.24

Formula

C8H19NO4
CAS No.
Appearance

Liquid (Density: 1.068±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (517.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (517.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1749 mL 25.8746 mL 51.7491 mL
5 mM 1.0350 mL 5.1749 mL 10.3498 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (517.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.73%

COA (240 KB) HNMR (124 KB) GC (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.1749 mL 25.8746 mL 51.7491 mL 129.3728 mL
5 mM 1.0350 mL 5.1749 mL 10.3498 mL 25.8746 mL
10 mM 0.5175 mL 2.5875 mL 5.1749 mL 12.9373 mL
15 mM 0.3450 mL 1.7250 mL 3.4499 mL 8.6249 mL
20 mM 0.2587 mL 1.2937 mL 2.5875 mL 6.4686 mL
25 mM 0.2070 mL 1.0350 mL 2.0700 mL 5.1749 mL
30 mM 0.1725 mL 0.8625 mL 1.7250 mL 4.3124 mL
40 mM 0.1294 mL 0.6469 mL 1.2937 mL 3.2343 mL
50 mM 0.1035 mL 0.5175 mL 1.0350 mL 2.5875 mL
60 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1562 mL
80 mM 0.0647 mL 0.3234 mL 0.6469 mL 1.6172 mL
100 mM 0.0517 mL 0.2587 mL 0.5175 mL 1.2937 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Amino-PEG4-alcohol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amino-PEG4-alcohol86770-74-3PROTAC LinkersADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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