Amino-PEG4-C2-SH hydrochloride

Cat. No.: HY-138446: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG4-C2-SH hydrochloride Chemical Structure

Size		Stock
100 mg		Get quote	Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

Biological Activity
Purity & Documentation
References
Customer Review

Description

Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.82

Formula

C₁₀H₂₄ClNO₄S

SMILES

SCCOCCOCCOCCOCCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (431.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4504 mL	17.2521 mL	34.5042 mL
5 mM	0.6901 mL	3.4504 mL	6.9008 mL
10 mM	0.3450 mL	1.7252 mL	3.4504 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4504 mL	17.2521 mL	34.5042 mL	86.2604 mL
	5 mM	0.6901 mL	3.4504 mL	6.9008 mL	17.2521 mL
	10 mM	0.3450 mL	1.7252 mL	3.4504 mL	8.6260 mL
	15 mM	0.2300 mL	1.1501 mL	2.3003 mL	5.7507 mL
	20 mM	0.1725 mL	0.8626 mL	1.7252 mL	4.3130 mL
	25 mM	0.1380 mL	0.6901 mL	1.3802 mL	3.4504 mL
	30 mM	0.1150 mL	0.5751 mL	1.1501 mL	2.8753 mL
	40 mM	0.0863 mL	0.4313 mL	0.8626 mL	2.1565 mL
	50 mM	0.0690 mL	0.3450 mL	0.6901 mL	1.7252 mL
	60 mM	0.0575 mL	0.2875 mL	0.5751 mL	1.4377 mL
	80 mM	0.0431 mL	0.2157 mL	0.4313 mL	1.0783 mL
	100 mM	0.0345 mL	0.1725 mL	0.3450 mL	0.8626 mL