Amino-PEG6-alcohol

Name: Amino-PEG6-alcohol
Brand: MedChemExpress
SKU: HY-126942
Rating: 4.5 (1 reviews)

Cat. No.: HY-126942 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG6-alcohol Chemical Structure

CAS No. : 39160-70-8

Size	Price	Stock	Quantity
50 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Non-cleavable Linker

PEGs

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

281.35

Formula

C₁₂H₂₇NO₆

CAS No.

39160-70-8

Appearance

Liquid (Density: 1.083±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (355.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5543 mL	17.7715 mL	35.5429 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (239 KB) HNMR (118 KB) RP-HPLC (221 KB) MS (82 KB)

Handling Instructions (2659 KB)

References

[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5543 mL	17.7715 mL	35.5429 mL	88.8573 mL
	5 mM	0.7109 mL	3.5543 mL	7.1086 mL	17.7715 mL
	10 mM	0.3554 mL	1.7771 mL	3.5543 mL	8.8857 mL
	15 mM	0.2370 mL	1.1848 mL	2.3695 mL	5.9238 mL
	20 mM	0.1777 mL	0.8886 mL	1.7771 mL	4.4429 mL
	25 mM	0.1422 mL	0.7109 mL	1.4217 mL	3.5543 mL
	30 mM	0.1185 mL	0.5924 mL	1.1848 mL	2.9619 mL
	40 mM	0.0889 mL	0.4443 mL	0.8886 mL	2.2214 mL
	50 mM	0.0711 mL	0.3554 mL	0.7109 mL	1.7771 mL
	60 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4810 mL
	80 mM	0.0444 mL	0.2221 mL	0.4443 mL	1.1107 mL
	100 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8886 mL