Aminooxy-PEG1-propargyl

Name: Aminooxy-PEG1-propargyl
Brand: MedChemExpress
SKU: HY-140056
Rating: 4.5 (1 reviews)

Cat. No.: HY-140056 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Aminooxy-PEG1-propargyl Chemical Structure

CAS No. : 1895922-69-6

Size	Price	Stock	Quantity
100 mg	USD 36	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 59	In-stock	Estimated Time of Arrival: December 31
1 g	USD 71	In-stock	Estimated Time of Arrival: December 31
5 g	USD 278	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1]. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

115.13

Formula

C₅H₉NO₂

CAS No.

1895922-69-6

Appearance

Liquid (Density: 1.035 g/cm³)

Color

Colorless to light yellow

SMILES

NOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (868.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.6858 mL	43.4292 mL	86.8583 mL
5 mM	1.7372 mL	8.6858 mL	17.3717 mL
10 mM	0.8686 mL	4.3429 mL	8.6858 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (267 KB) SDS (477 KB)

COA (242 KB) HNMR (124 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.6858 mL	43.4292 mL	86.8583 mL	217.1458 mL
	5 mM	1.7372 mL	8.6858 mL	17.3717 mL	43.4292 mL
	10 mM	0.8686 mL	4.3429 mL	8.6858 mL	21.7146 mL
	15 mM	0.5791 mL	2.8953 mL	5.7906 mL	14.4764 mL
	20 mM	0.4343 mL	2.1715 mL	4.3429 mL	10.8573 mL
	25 mM	0.3474 mL	1.7372 mL	3.4743 mL	8.6858 mL
	30 mM	0.2895 mL	1.4476 mL	2.8953 mL	7.2382 mL
	40 mM	0.2171 mL	1.0857 mL	2.1715 mL	5.4286 mL
	50 mM	0.1737 mL	0.8686 mL	1.7372 mL	4.3429 mL
	60 mM	0.1448 mL	0.7238 mL	1.4476 mL	3.6191 mL
	80 mM	0.1086 mL	0.5429 mL	1.0857 mL	2.7143 mL
	100 mM	0.0869 mL	0.4343 mL	0.8686 mL	2.1715 mL