Aminooxy-PEG2-azide

Name: Aminooxy-PEG2-azide
Brand: MedChemExpress
SKU: HY-113931
Rating: 4.5 (1 reviews)

Cat. No.: HY-113931 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Aminooxy-PEG2-azide Chemical Structure

CAS No. : 1043426-13-6

Size	Price	Stock	Quantity
25 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 720	Get quote	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[2]. Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target^[1]^[2]

PEGs	Non-cleavable Linker

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

190.20

Formula

C₆H₁₄N₄O₃

CAS No.

1043426-13-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCCOCCOCCON

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (525.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2576 mL	26.2881 mL	52.5762 mL
5 mM	1.0515 mL	5.2576 mL	10.5152 mL
10 mM	0.5258 mL	2.6288 mL	5.2576 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (240 KB) HNMR (116 KB)

Handling Instructions (2659 KB)

References

[1]. H. Tetsuo Uyeda, et al. Synthesis of surface ligands to prepare hydrophilic and biologically compatible quantum dots. doi: 10.1117/12.590494.

[2]. Song, Ho Young, et al. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2576 mL	26.2881 mL	52.5762 mL	131.4406 mL
	5 mM	1.0515 mL	5.2576 mL	10.5152 mL	26.2881 mL
	10 mM	0.5258 mL	2.6288 mL	5.2576 mL	13.1441 mL
	15 mM	0.3505 mL	1.7525 mL	3.5051 mL	8.7627 mL
	20 mM	0.2629 mL	1.3144 mL	2.6288 mL	6.5720 mL
	25 mM	0.2103 mL	1.0515 mL	2.1030 mL	5.2576 mL
	30 mM	0.1753 mL	0.8763 mL	1.7525 mL	4.3814 mL
	40 mM	0.1314 mL	0.6572 mL	1.3144 mL	3.2860 mL
	50 mM	0.1052 mL	0.5258 mL	1.0515 mL	2.6288 mL
	60 mM	0.0876 mL	0.4381 mL	0.8763 mL	2.1907 mL
	80 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6430 mL
	100 mM	0.0526 mL	0.2629 mL	0.5258 mL	1.3144 mL