2. Membrane Transporter/Ion Channel Autophagy
  3. Potassium Channel Autophagy
  4. Amiodarone-d10 hydrochloride

Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].

For research use only. We do not sell to patients.

Amiodarone-d<sub>10</sub> hydrochloride Chemical Structure

Amiodarone-d10 hydrochloride Chemical Structure

CAS No. : 1261393-77-4

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5 mg USD 800 In-stock
10 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Amiodarone-d10 hydrochloride:

Amiodarone-d10 hydrochloride Related Antibodies

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Description

Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amiodarone-d10 hydrochloride Related Antibodies
Molecular Weight

691.83

Formula

C25H20D10ClI2NO3
CAS No.
Unlabeled CAS

1951-25-3
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC(I)=C(C(I)=C1)OCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C2=C(CCCC)OC3=CC=CC=C23.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (289.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4454 mL 7.2272 mL 14.4544 mL
5 mM 0.2891 mL 1.4454 mL 2.8909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4454 mL 7.2272 mL 14.4544 mL 36.1360 mL
5 mM 0.2891 mL 1.4454 mL 2.8909 mL 7.2272 mL
10 mM 0.1445 mL 0.7227 mL 1.4454 mL 3.6136 mL
15 mM 0.0964 mL 0.4818 mL 0.9636 mL 2.4091 mL
20 mM 0.0723 mL 0.3614 mL 0.7227 mL 1.8068 mL
25 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4454 mL
30 mM 0.0482 mL 0.2409 mL 0.4818 mL 1.2045 mL
40 mM 0.0361 mL 0.1807 mL 0.3614 mL 0.9034 mL
50 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
60 mM 0.0241 mL 0.1205 mL 0.2409 mL 0.6023 mL
80 mM 0.0181 mL 0.0903 mL 0.1807 mL 0.4517 mL
100 mM 0.0145 mL 0.0723 mL 0.1445 mL 0.3614 mL
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Amiodarone-d10 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amiodarone-d101261393-77-4Potassium ChannelAutophagyKcsAInhibitorinhibitorinhibit

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